Antiepileptic drugs and suicidality

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Antiepileptic drugs and suicidality

The risk of suicide in patients with epilepsy is significantly higher than the general population. There are many hypotheses as to the reasons for this, but the potential role of anti-epileptic drugs (AEDs) in increasing suicidality has recently been brought into question. In 2008, the U.S. Food and Drug Administration (FDA) published a warning after a meta-analysis of data from all clinical tr...

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Antiepileptic drugs and suicidality.

The current study is a systematic review of the literature concerning the possible relationship of antiepileptics and suicide-related clinical features and behaviours. A MEDLINE search returned 863 papers but only five were chosen as relevant. A critical analysis of the Food and Drug Administration report is also included. Overall, the current review suggests there are no convincing data concer...

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Suicidality in people taking antiepileptic drugs: What is the evidence?

Suicide is an important cause of premature death. In the general population, most people who commit suicide have a psychiatric problem at the time. People with epilepsy are thought to be at increased risk from suicide and suicidality (suicidal ideation or behaviour). Standardized mortality ratios estimated for suicide in people with epilepsy are usually between 3 and 5. Risk factors for suicide...

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GENERIC NAME PAGE Carbamazepine 378 Clobazam 381 Clonazepam 380 Clorazepate 381 Diazepam 383 Ethosuximide 381 Ethotoin 378 Felbamate 382 Fosphenytoin 383 Gabapentin 382 Levetiracetam 382 Lamotrigine 379 Lorazepam 380 GENERIC NAME PAGE Mephenytoin 378 Mephobarbital 381 Metharbital 381 Nitrazepam 381 Oxcarbazepine 379 Phenobarbital 381 Phenytoin 377 Primidone 381 Tiagabine 381 Topiramate 379 Valp...

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ژورنال

عنوان ژورنال: Drug, Healthcare and Patient Safety

سال: 2010

ISSN: 1179-1365

DOI: 10.2147/dhps.s13225